Tetrahydrofuran (THF) is a colorless, flammable liquid with a distinctive odor. Its chemical formula is C4H8O, and it has a molecular weight of 72.11 g/mol. Tetrahydrofuran can react with various organic compounds and possesses moderate solubility, making it a commonly used organic solvent.
| Property | Value |
|---|---|
| CAS Number | 109-99-9 |
| EINECS Number | 203-726-8 |
| Chemical Formula | C4H8O |
| Molecular Weight | 72.11 g/mol |
| Density at 20 °C | 0.887 g/mL |
| Melting Point | -108 °C |
| Boiling Point | 66 °C |
| Flash Point | 6 °F (-14 ℃) |
| Water Solubility | Miscible |
| Vapor Pressure (25 °C) | <0.01 mm Hg |
| Vapor Density (vs air) | 2.5 |
| Solubility | Water: Soluble |
THF finds widespread applications in biochemistry and organic synthesis. It serves as a solvent, intermediate, and stabilizer for catalysts. In pharmaceutical synthesis, THF is employed in the production of esters, ethers, amides, and hormone-like compounds. It is also frequently used as a reaction medium in polymerization reactions.
Several methods exist for the synthesis of tetrahydrofuran. One approach involves the hydrogenation of furan, typically carried out in the presence of hydrogen gas and a catalyst. Another method involves the reaction of epichlorohydrin with aqueous ammonia.
When handling tetrahydrofuran, attention should be paid to its safety information. THF possesses some toxicity and corrosiveness, necessitating precautions to avoid direct contact with the skin and eyes. Proper protective gear, including gloves, goggles, and protective clothing, should be worn during usage. Additionally, THF is flammable, and precautions should be taken to keep it away from open flames and heat sources, storing it in a cool and well-ventilated area. Proper disposal procedures in accordance with regulations should be followed to minimize environmental impact when dealing with waste.
Other Names for Tetrahydrofuran:
THF
oxolane
Furanidine
Tetrahydrofuran
Diethylene oxide
Furan, tetrahydro-
Butane, alpha,delta-oxide
Cyclotetramethylene oxide
Sodium tri-sec-butylborohydride
1,2,3,4-tetrahydro-9H-fluoren-9-one
TETRAMETHYLENE ETHER GLYCOL 2000 POLYMER
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