Phenacetin, also known as acetophenetidin, is a medication. It is a white crystalline solid, soluble in alcohol and chloroform, typically stable at room temperature. It acts as a central nervous system depressant and can be used as a sedative, hypnotic, and anticonvulsant medication.
Phenacetin is commonly used to treat seizures, anxiety, and sleep disorders. As a sedative, it helps relax muscles and alleviate anxiety. As a hypnotic, it aids in inducing sleep. However, the use of phenacetin should be guided by a physician as it carries addictive potential and risk of misuse.
The production of phenacetin primarily involves the hydrogenation reaction of the main raw material, acetophenone, to obtain phenobarbital sodium, followed by acidification to yield phenacetin.
When using phenacetin, certain safety considerations should be noted. Firstly, it should not be used with alcohol, sedatives, or other central nervous system depressants to avoid increasing the risk of adverse reactions. Secondly, long-term or excessive use should be avoided to prevent addiction and drug dependence. Additionally, some common side effects include dizziness, fatigue, sluggishness, lack of concentration, and insomnia. If severe allergic reactions or other discomfort symptoms occur, discontinuation of the medication and seeking medical attention is advised.
Here is the overview of its chemical’s properties:
| Property | Value |
|---|---|
| CAS | 62-44-2 |
| EINECS | 200-533-0 |
| Chemical Formula | C10H13NO2 |
| Molecular Weight | 179.22 |
| Density | 1.1248 (rough estimate) |
| Melting Point | 133-136°C (lit.) |
| Boiling Point | 132°C / 4mmHg |
| Flash Point | 2°C |
| Water Solubility | 0.076 g/100 mL |
| Vapor Pressure | 3.21E-05mmHg at 25°C |
| Solubility | Chloroform (slightly soluble), Methanol (slightly soluble) |
| Refractive Index | 1.5710 |
| Acidity Constant | pKa 2.2(H2O) (Uncertain); 3.5(aqueous acetone) (Uncertain) |
| Storage Conditions | Sealed in dry, Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
| Sensitivity | Hygroscopic |
| Appearance | Powder |
| Color | White |
Other name for Phenacetin:
pyraphen
phenacet
coricidin
phenazetin
phenacitin
Phenacetin
Phorazetim
acetophenetin
Para-phenacetin
ACETOPHENETIDIN
ACETOPHENETIDINE
acetylphenetidin
p-acetophenetide
acet-p-phenalide
p-acetphenetidin
Acetophenetidine
empirin compound
paracetophentidin
acet-p-phenetidin
p-acetophenetidine
ACET-P-PHENETIDINE
4-ACETOPHENETIDIDE
4-acetophenetidine
p-Ethoxyacetanilide
4′-ethoxyacetanilide
ACETYL-P-PHENETIDINE
4′-ETHOXYACETANILIDE
aceto-para-phenalide
para-Acetophenetidide
1-ACETYL-P-PHENETIDIN
aceto-para-phenetidide
N-acetyl-p-phenetidine
N-Acetyl-4-ethoxyaniline
1-acetamido-4-ethoxybenzene
N-(4-ethoxyphenyl)-acetamide
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